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. 2018 Jun 29;11:418. doi: 10.1186/s13104-018-3507-2

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — A formal description of the graph representation and workflow used by GrapHi-C. a The mathematical model used to represent a contact map as an undirected graph in the GrapHi-C protocol. b Overview of the GrapHi-C protocol. Each step of the workflow is indicated in a box where the different colours correspond to: data input and output (grey), developed Perl script (purple), and an existing tool (orange). An option for scaling the interaction frequencies is available in the developed Perl script if future studies wish to use it