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. 2018 Jun 13;12(6):e0006575. doi: 10.1371/journal.pntd.0006575

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© 2018 Chadha et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 6 — (A) 2D structure of borrelidin (B) Dose-response inhibition of the aminoacylation activity of rLdThrRS in the presence of known ThrRS inhibitor, borrelidin. Inhibitor concentrations are plotted in the log scale on X-axis. The experiment was performed with 0.001–10 μM borrelidin. (C) Top Panel: ITC profile for binding of rLdThrRS to borrelidin indicating the sequential injection of the drug into rLdThrRS after correction of the heat of dilution of the drug. Bottom panel: Plot of integrated heat data fitted to a one-site model at 25°C. (D) Bar diagram is describing the variation of the magnitude of thermodynamic parameters of binding of borrelidin to rLdThrRS.