Table 4.

Prevalent early AMD by tertiles of dietary xanthophyll intake (visit 1), stratified by plasma biomarkers of HDL cholesterol metabolism (n=10,295).

	Outcome n/ Total n	Multivariable-adjusted OR (95% CI)*			p-value for trend‡	p-value for multiplicative interaction
		Tertile 1┼ (322-799)	Tertile 2 (1014-1383)	Tertile 3 (2027-3996)
HDL (mmol/L)†
<1.27	271/5122	referent	1.15 (0.87-1.54)	0.79 (0.57-1.09)	0.86	0.048
≥1.27	264/5173	referent	0.98 (0.71-1.36)	1.14 (0.83-1.58)	0.88
HDL2 (mmol/L)
<0.33	283/5039	referent	1.17 (0.88-1.55)	0.82 (0.59-1.13)	0.69	0.066
≥0.33	252/5256	referent	0.96 (0.69-1.33)	1.11 (0.80-1.54)	0.67
HDL3 (mmol/L)
<0.95	283/5198	referent	1.19 (0.89-1.59)	0.96 (0.70-1.31)	0.92	0.46
≥0.95	252/5097	referent	0.94 (0.68-1.29)	0.95 (0.69-1.33)	0.89
ApoA1 (μmol/L)
<46.26	278/5103	referent	1.22 (0.92-1.63)	0.86 (0.62-1.19)	0.73	0.067
≥46.26	257/5192	referent	0.90 (0.65-1.25)	1.05 (0.76-1.44)	0.70

^*Adjusted for age, sex, race, pack-years of smoking, field center, visit 1 daily caloric intake,

^†HDL, HDL2, HDL3 and ApoA1 were categorized by median split

^┼Tertiles and interquartile range (μg/1000 kcal) of energy-adjusted daily xanthophyll intake at visit 1

^‡P-value of the association between xanthophyll intake (continuous, μg/1000 kcal) and odds of prevalent early AMD within lipid biomarker category