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. 2018 Jun 18;128(7):3186–3197. doi: 10.1172/JCI98931

Figure 4. Implantation failure in Hif2a-uKO mice is not triggered by ovarian factors but by uterine factors.

Figure 4

(A) A scheme of transplantation of WT ovaries into Hif2a-uKO mice or the littermate controls with ovariectomy. (B and C) Ovarian transplantation of WT ovaries in Hif2a-uKO mice did not rescue the phenotype of implantation failure observed in those without ovarian transplantation. In B, scale bar, 500 μm; arrowhead, an embryo; arrow, a destroyed embryo with blood cell infiltration; dec, decidua. In C, P > 0.05, mean ± SEM, Student’s t test. (D) Ovarian Hif2a mRNA levels were comparable between Hif2a-uKO mice and their controls. P > 0.05, n = 5, mean ± SEM, Student’s t test.