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. 2018 Jun 18;128(7):3186–3197. doi: 10.1172/JCI98931

Figure 8. Stromal Hif2a is critical for embryo invasion and PI3K-AKT pathway is activated in the implanting embryos.

Figure 8

(A–C) Infertility phenotype with both impaired embryo invasion and persistent presence of luminal epithelium was observed in Hif2a-sKO mice. In A and B, *P < 0.05, mean ± SEM, Student’s t test. In C, scale bar, 200 μm; arrowhead, an embryo; s, stroma; arrow, a destroyed embryo with blood cell infiltration. (D) Hif2a-eKO mice demonstrated normal fertility. P > 0.05, mean ± SEM, Student’s t test. (E) Intensity of phosphorylated AKT staining was strong in the control trophoblast compared with Hif2a-uKO one. (F and G) Expression of VEGF and ADM at the stroma of implantation sites collected by laser capture microdissection was decreased in Hif2a-uKO mice. *P < 0.05, mean ± SEM, Student’s t test.