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. 2018 Jun 4;128(7):2951–2965. doi: 10.1172/JCI98727

Figure 7. SA1 depletion sensitizes SA2-mutated cells to the treatment of PARP inhibitors.

Figure 7

(A and B) SA1 depletion sensitizes the SA2-mutated RT4 cells to the treatment of PARP inhibitors. Representative images (A) and quantitative results (B) of cell survival are shown. Parental and isogenic SA2-mutated RT4 cells expressing control or SA1 siRNA were treated with indicated PARP inhibitors for 72 hours. (C) Dose-dependent responses of the SA2-intact or -mutated cell lines to the treatment of olaparib (72 hours) with or without SA1 KD. **P < 0.01; ***P < 0.001; ****P < 0.0001, unpaired 2-tailed t test. Data are presented as mean ± SD and are representative of 3 independent experiments.