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. 2018 Jun 11;128(7):2996–3007. doi: 10.1172/JCI95993

Figure 3. MYC expression and activity in CD30+ B cells.

Figure 3

Expression of MYC and MYC target genes in CD30+ and conventional B cells. Enrichment plots of functionally validated MYC target genes (482 Myc high) (69) for comparisons of (A) CD30+ versus conventional (Conv.) GC B cells, (B) CD30+ EF B cells versus memory B cells, and (C) CD30+ EF B cells versus plasma cells (PC). (D) A comparison of CD30+ GC B cells versus conventional GC B cells is shown for a gene set specifically enriched in murine MYC+ GC B cells, and a gene set enriched in murine MYC– GC B cells (42). (E) MYC expression in tonsillar CD30– cells (M, memory B cells; PC, plasma cells) and CD30+ GC and EF B cell subsets by RT-qPCR (n = 6 donors). Ct values are shown. Graphs indicate mean ± SD. (F) MYC protein expression in CD30+ B cells, CD30– GC B cells, and memory (M) B cells. A representative image of 2 independent experiments is shown. *P < 0.05; **P < 0.01, ***P < 0.001 (unpaired, 2-tailed t test).