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. 2018 Jun 18;128(7):3129–3143. doi: 10.1172/JCI96060

Figure 1. TRAF4 is overexpressed in prostate cancers.

Figure 1

(A) TRAF4 mRNA is upregulated in prostate tumors (n = 39) as compared with normal tissue (n = 9) in a prostate cancer tissue scan array (OriGene) as analyzed by RT-qPCR. Left: Relative TRAF4 mRNA expression in normal and tumor samples as normalized against β-actin. *P < 0.05 by Mann-Whitney U test. Right: Average fold induction of TRAF4 expression in tumor samples. *P < 0.05 by 2-tailed Student’s t test. (B) TRAF4 protein is upregulated in human prostate tumors (T) compared with matched benign tissue (N) samples (n = 10 each) as analyzed by Western blot. (C–F) TRAF4 is highly expressed in metastatic prostate cancers. The expression of TRAF4 was analyzed in 4 different prostate cancer datasets: Chandran and Yu, refs. 37, 38; Grasso, ref. 39; Taylor, ref. 35; Varambally, ref. 36 and presented as mean ± SEM. β-Actin was used as an internal control. *P < 0.05 by 1-way ANOVA with multiple comparisons test. PC, prostate cancer; CRPC, castration-resistant prostate cancer.