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Secondary structure of SMN2 intron 7 derived from chemical probing. Numbering starts from the first position of intron 7. Negative numbers represent upstream sequences within exon 7. TSLs, ISTLs and binding sites for TIA1 and hnRNP A1/A2B1 are shown and highlighted. ISS-N2 is composed of the 3′ strands of ISTL1, ISTL2 and ISTL3 [43, 50]. The 5′ss of exon 7 is indicated by a red arrow. Abbreviations are given in Table 2.
