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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Exp Physiol. 2018 Jun 8;103(7):941–955. doi: 10.1113/EP087006

Table 1.

Subject characteristics by randomized group at baseline and after interventions. Data shown are mean (SD), median (interquartile range), or n (%). RM-ANOVA revealed no statistically significant differences for group-by-time interaction.

Allopurinol
(n=30)
Losartan
(n=28)
Placebo (n=28) P-value* P-value
Sex (female) 10 (33%) 15 (54%) 9 (32%) 0.180 -----

Age (yr) 49 (8) 49 (12) 47 (9) 0.677 -----

Body mass index (kg/m2)
 Initial 38.2 (7.2) 38.6 (7.4) 34.5 (6.6) 0.061
 Final 38.6 (7.1) 39.1 (7.6) 34.8 (6.4) 0.062 0.579

Height (m)
 Initial 1.74 (0.10) 1.74 (0.11) 1.73 (0.11) 0.851
 Final 1.74 (0.10) 1.74 (0.10) 1.73 (0.11) 0.893 0.952

Weight (kg)
 Initial 116.6 (26.4) 118.5 (30.4) 103.3 (22.5) 0.071
 Final 117.2 (25.6) 119.5 (30.7) 103.9 (21.8) 0.078 0.504

Apnoea-hypopnoea index (events/hr)
33 (24-50) 46 (27-58) 35 (18-59) 0.653
45 (22-68) 44 (25-67) 26 (15-62) 0.358 0.070

Respiratory distress index (events/hr)
 Initial 37 (25-51) 49 (27-60) 42 (24-61) 0.734
 Final 50 (22-69) 50 (25-67) 31 (20-64) 0.445 0.074

Time <88% SaO2 (%)
 Initial 5 (1-15) 10 (4-25) 5 (1-9) 0.208
 Final 8 (2-18) 12 (2-35) 3 (1-8) 0.097 0.269

Fasting blood glucose (mg/dL)
 Initial 94 (15) 96 (10) 91 (10) 0.330
 Final -----

Triglycerides (mg/dL)
 Initial 145 (56) 150 (49) 139 (62) 0.759
 Final -----

post-intervention measurements not obtained (these were inclusion criteria)

*

P-value for between-group comparison at each time point

P-value for group-by-time interaction, adjusted for average daily CPAP use (min)