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. Author manuscript; available in PMC: 2018 Dec 20.
Published in final edited form as: Nature. 2018 Jun 20;558(7711):610–614. doi: 10.1038/s41586-018-0238-4

Figure 4. ddhCTP inhibits Flavivirus RdRps by a chain termination mechanism.

Figure 4

a, ddhCTP (0, 1, 10, 100 and 300 μM) inhibits DV RdRp. Experiments repeated independently four times with similar results. b, Plot of [ddhCMP Inc.] / [CMP Inc.] versus [ddhCTP] / [CTP]. Data fit to a line with slope of 0.0074 ± 0.0006 (DV) and 0.017 ± 0.002 (WNV). At each ratio of [ddhCTP] /[CTP] a total of at least 3 independent experiments, with total sample size of 24. c, Inhibition of WNV, ZV and HCV RdRps with either ddhCTP or 3′-dCTP (100 μM). Experiments repeated independently four to five times with similar results. d, Percentage of inhibition shown. Error bars represent SEM (n = 4 independent experiments).