EEAA versus (A) neurology class (x-axis), (B) attention, (C) working memory, (D) executive functioning E) processing speed in all adolescents (both HIV+ and HIV-). Points are colored by HIV status (red=HIV+, black=HIV-). (F–i) reports analogous findings for HIV+ adolescents, i.e. HIV- controls were omitted. Overall, increased epigenetic age acceleration is associated with impaired cognitive functioning. The title of panel A reports a Kruskal Wallis test p-value while the remaining panels report Pearson correlation test p values.