Table 2.

Primary and Secondary Outcomes in the Propensity-Matched Cohort

	No Platelet Transfusion (N=985)	Platelet Transfusion (N=985)
Outcome	Event (%)	Event (%)	OR (95% CI)†	p-value†
RBC transfusion within 24 hours	102 (10.4%)	456 (46.3%)	7.5 (5.9, 9.5)	<0.001
ICU mortality	90 (9.1%)	101 (10.3%)	1.1 (0.8, 1.5)	0.403
All-cause 30-day mortality	162 (16.4%)	184 (18.7%)	1.2 (0.9, 1.5)	0.193
Outcome	Mean (SD)	Mean (SD)	Mean Rate Ratio (95% CI)‡	p-value‡
ICU-free days	22.7 (8.3)	20.8 (9.1)	0.9 (0.9, 1.0)	0.004
Hospital-free days	15.8 (9.4)	13.0 (9.7)	0.8 (0.7, 0.9)	<0.001
Outcome	Mean (SD)	Mean (SD)	Mean Difference (95% CI)§	p-value§
Change in SOFA score*	−1.8 (3.3)	−0.2 (3.6)	1.5 (1.2, 1.8)	<0.001

CI – confidence interval, ICU – intensive care unit, RBC – red blood cell, SOFA – sequential organ failure assessment, SD – standard deviation.

^†Estimate and p-value comes from logistic regression. An odds ratio > 1 implies increased odds for the outcome in those receiving platelet transfusions.

^‡Estimate and p-value comes from negative binomial regression. A rate ratio < 1 implies decreased mean for the outcome in those receiving platelet transfusions. Specifically, a rate ratio of 0.9 can be interpreted as a 10% decrease in the mean for those receiving platelet transfusions compared to those who did not.

^*Change in SOFA score defined as 24-hr SOFA score – Baseline SOFA score, with negative values reflecting improvement in SOFA scores in the ensuing 24 hours.

^§Estimate and p-value comes from linear regression. A mean difference > 0 implies less improvement in SOFA score in those receiving platelet transfusions.