Table 3.
Primary and Secondary Outcomes in the Propensity-Matched Cohort With Platelet Counts ≤ 50 × 109/L
| No Platelet
Transfusion (N=229) |
Platelet
Transfusion (N=229) |
|||
|---|---|---|---|---|
| Outcome | Event (%) | Event (%) | OR (95% CI)† | p-value† |
| RBC transfusion within 24 hours | 29 (12.7%) | 106 (46.3%) | 5.9 (3.7, 9.5) | <0.001 |
| ICU mortality | 40 (17.5%) | 41 (17.9%) | 1.0 (0.6, 1.7) | 0.903 |
| All-cause 30-day mortality | 75 (32.8%) | 81 (35.4%) | 1.1 (0.8, 1.7) | 0.554 |
|
| ||||
| Outcome | Mean (SD) | Mean (SD) | Mean Rate Ratio (95% CI)‡ | p-value‡ |
| ICU-free days | 19.9 (10.5) | 18.3 (10.6) | 0.9 (0.8, 1.1) | 0.399 |
| Hospital-free days | 10.2 (10.0) | 7.8 (9.4) | 0.8 (0.5, 1.1) | 0.144 |
|
| ||||
| Outcome | Mean (SD) | Mean (SD) | Mean Difference (95% CI)§ | p-value§ |
| Change in SOFA score* | −0.3 (2.9) | −0.5 (3.5) | −0.2 (−0.8, 0.4) | 0.553 |
CI – confidence interval, ICU – intensive care unit, RBC – red blood cell, SOFA – sequential organ failure assessment, SD – standard deviation.
Estimate and p-value comes from logistic regression. An odds ratio > 1 implies increased odds for the outcome in those receiving platelet transfusions.
Estimate and p-value comes from negative binomial regression. A rate ratio < 1 implies decreased mean for the outcome in those receiving platelet transfusions. Specifically, a rate ratio of 0.9 can be interpreted as a 10% decrease in the mean for those receiving platelet transfusions compared to those who did not.
Change in SOFA score defined as 24-hr SOFA score – Baseline SOFA score, with negative values reflecting improvement in SOFA scores in the ensuing 24 hours.
Estimate and p-value comes from linear regression. A mean difference > 0 implies less improvement in SOFA score in those receiving platelet transfusions