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. Author manuscript; available in PMC: 2019 Apr 14.
Published in final edited form as: Bioorg Med Chem Lett. 2017 Dec 29;28(3):244–248. doi: 10.1016/j.bmcl.2017.12.064

Scheme 1.

Scheme 1

Reagents and conditions: (a) N,N-diisopropylethylamine, CH2Cl2, rt, 12 h (2, 17, 18); (b) THF, 25–80 °C; 12 h (6–9, 19, 20); (c) CH3CN, 80 °C, 12 h (10–16); (d) CDI, THF, rt, 48 h (3, 4); (e) CDI, 1,2-dimethoxyethane, reflux, 16 h (5).