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. 2018 Jun 29;8:9821. doi: 10.1038/s41598-018-28183-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increased NFκB staining. (A) Retinas were labeled with an anti-NFκB antibody (green) and DAPI (blue). (B) At 3 days, no changes were observed in regard of the number of NFκB⁺ cells in the S100 group (p > 0.05). After 7 days, significantly more NFκB⁺ cells were noted in S100 animals (p = 0.03). A significant increase of NFκB⁺ cells was still revealed in this group after 14 days (p = 0.03). (C) QRT-PCR analysis revealed no differences in Nfκb mRNA expression at all points in time (p > 0.05). However, a slight trend towards an upregulation could be observed at 7 days (p = 0.18). (D) The expression levels of Myd88 showed a trend towards an upregulation at 3 days (p = 0.1). At 7 and 14 days, no alterations were noted (p > 0.05). (E) At all points in time, the expression of NEMO mRNA remained unchanged (p > 0.05). Abbreviation: GCL = ganglion cell layer. Values are mean ± SEM for immunohistology and median ± quartile + maximum/minimum for qRT-PCR. Scale bars: 20 µm.