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. 2018 Jun 29;8:9839. doi: 10.1038/s41598-018-28209-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Axon regeneration stimulated by Pten KD after 1 s or 5 s ONC. (A,B) Representative images of the optic nerve longitudinal sections with CTB-labeled axons through the optic nerve, 2 weeks after 1 s (A) or 5 s (B) ONC. (C,D) Representative image of the optic nerve longitudinal sections with CTB-labeled axons regenerating through the optic nerve, 2 weeks after 1 s (C) or 5 s (D) ONC and pre-treatment with anti-Pten shRNA AAV2. The edges of the tissue were cropped out due to artefactual autofluorescence that is common at tissue edges. Insets: Representative images of the optic nerve regions proximal and distal to the injury site are magnified for better visualization of the axons or their absence. Scale bars, 500 µm (main panels), 100 µm (insets).