Fig. 1.

ISLE framework and the clinical-SL-network. a The three step inference procedure of ISLE and the datasets used in each step (Methods). b The core clinical-SL-network (with FDR < 0.1) includes 2326 interactions between 2153 genes, where the gene names having more than 10 cSL partners are marked; the size of nodes is proportional to the number of interactions they have). The complete network with FDR < 0.2 (the correction level used in all analyses presented in the paper) is provided in Supplementary Fig. 1 and in an interactive form at GitHub: https://github.com/jooslee/ISLE/