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. 2018 Jun 29;9:2541. doi: 10.1038/s41467-018-04802-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Selectivity of detection of the DNA equivalent of miRNA-126, i.e. DmiRNA-126. a The target molecule with three different detection molecules. 8 bpD is a detection molecule with 8-bp perfect match to the target. 9 bpMM is a detection molecule with 8-bp perfect match and a single mismatch in the middle. 9 bpD is a detection molecule with 9-bp perfect match with the DmiRNA-126 target. Perfect match is indicated in blue and mismatch is indicated in red. b Detection of 100 pM DmiRNA-126 with 8 bpD, 9 bpMM, and 9 bpD detection molecules. The used capture molecule on the particle has 11-bp complementarity to the target. Particle switching activities were recorded before and after supply of 100 pM DmiRNA-126 target. c Particle switching activity using 9 bpD detection molecule and different target oligonucleotide sequences. Sequentially, particle-switching activities were recorded when there was no target injected, when 100 pM target with a random DNA sequence was injected, and finally when 100 pM DmiRNA-126 target was injected. Error bars are standard deviations of two independent measurements with 5 min duration