(A) Baseline respiratory symptoms and percentage of subjects with abnormal lung function (FEV1 < LLN) among those with and without bronchial hyperreactivity at baseline. Provocability was not available at baseline. (B) Follow-up respiratory symptoms and percentage with FEV1 < LLN among those with and without bronchial hyperreactivity at follow-up. All symptoms were less prevalent at follow-up than at baseline (P < .001). At follow-up, dyspnea and provocability of respiratory symptoms (3 or more vs. less than 3) were significantly more prevalent (OR, 2.28 [1.09-4.73], and OR, 3.89 [1.61-9.39], respectively) among those with BHR than among without BHR. BHR = bronchial hyperreactivity; LLN = lower limit of normal.