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Effect of dFEV1 on exacerbation RD. Each comparison is represented by a circle. The circle sizes are proportional to the contribution of individual studies toward the linear prediction, which was the inverse of the SE. The regression line is in solid black with 95% CIs shown. The unit for dFEV1 in the regression equation is 100 mL. dFEV1 = between-group difference in change in predose (trough) FEV1 from the beginning to the end of trial; RD = rate difference.
