Table 1.
FDNY Sarcoidosis Evaluation Protocol at Diagnosis and Follow-up
| Variable | Examination Description at Diagnosis | Examination Description at Follow-up |
|---|---|---|
| Questionnaire | • Occupational, medical, family, and sarcoidosis history | • Occupational, medical, family, and sarcoidosis history |
| • Racial/ethnic background | • Racial/ethnic background | |
| • WTC exposure details | • WTC exposure details | |
| • Tobacco use history | • Tobacco use history | |
| • Review of systems | • Review of systems | |
| • Medication use | • Medication use, including current and past treatment for sarcoidosis (corticosteroids and other disease-modifying drugs) | |
| General physical examination | • Cardiac and pulmonary auscultation | • Cardiac and pulmonary auscultation |
| • Abdominal palpation | • Abdominal palpation | |
| • Lymph node, joint, and skin surveys | • Lymph node, joint, and skin surveys | |
| • Cranial nerves, motor and sensory perception assessments | • Cranial nerves, motor and sensory perception assessments | |
| Eye examination by an ophthalmologist | • Examination of eyelids | • Examination of eyelids |
| • Palpebral fissures | • Palpebral fissures | |
| • Conjunctivae for granulomas | • Conjunctivae for granulomas | |
| • Slit lamp and dilated retina exam | • Slit lamp and dilated retina exam | |
| Chest imaging | • Chest radiographs (PA and lateral) or recreated digitally from CT imaging | • Chest radiographs (PA and lateral) or recreated digitally from CT imaging |
| • Noncontrast chest CT scan | • Noncontrast chest CT scan | |
| Pulmonary function | • Spirometry | • Spirometry |
| • Lung volumes | • Lung volumes | |
| • Diffusing capacity | • Diffusing capacity | |
| Oxygen saturation | • At rest | • At rest and on exercise (6-min walk) |
| Cardiac evaluation | • 12-lead ECG | • 12-lead ECG |
| • Transthoracic echocardiogram | • Transthoracic echocardiogram | |
| • 24-h continuous recording | • 48-h continuous recording | |
| • Cardiac MRI with gadolinium | ||
| Blood analyses | • CBC count | • CBC count |
| • Metabolic panel | • Metabolic panel | |
| • Creatinine and ionized calcium | • Creatinine and ionized calcium | |
| • Liver enzyme levels | • Liver enzyme levels | |
| • Angiotensin-converting enzyme | ||
| • Vitamin D (25-hydroxy and 1,25 dihydroxy) | ||
| • Beryllium testing (IFN-γ ELISpot assay and beryllium lymphocyte proliferation test [BeLPT]) | ||
| Urinalyses | • Urinalysis (microscopic and chemistry) | • Urinalysis (microscopic and chemistry) |
| • 4-h collection for creatinine and calcium |
FDNY = Fire Department of the City of New York; PA = posterioranterior; WTC = World Trade Center.