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. 2016 Jan 13;149(5):1313–1324. doi: 10.1016/j.chest.2015.11.016

Table 6.

Possible Factors Associated with Restrictive Physiology in Sickle Cell Disease

  • Acute or chronic inflammation

  • Recurrent episodes of acute chest syndrome

  • Small-vessel vascular volume on CT scanning

  • Cardiomegaly (increased cardiac-to-thoracic ratio)