Fig. 4.

Sustained administration of C2816 induces body weight loss and metabolic improvements in DIO C57BL6 mice, superior to co-infusion of CCKR1 agonist peptide (AC170222) and GLP-1 analog (AC3174) parent molecules. *p < 0.05 vs. vehicle, ˆp < 0.05 vs. AC3174, +p < 0.05 vs. AC170222, #p < 0.05 vs. (pGlu-Gln)-CCK-8/exendin-4, ^ap<0.05 for C2816 group vs. all other groups at all study days, ^bp < 0.05 for AC3174 vs. vehicle, AC170222 and (pGlu-Gln)-CCK-8/exendin-4 groups at all study days, ^cp < 0.05 vs. all other groups.