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Acute administration of C2816 does not induce pica behavior in lean rats. Intake of chow at 4 h and 24 h (A, C), and the non-nutritive clay kaolin (B, D) in overnight fasted Sprague Dawley rats administered vehicle, cisplatin (10 mg/kg) or C2816 (7 or 50 nmol/kg). Change in body weight over the 24 h observation period was also recorded (E). *p < 0.05 vs. vehicle, ˆp < 0.05 vs. cisplatin, +p < 0.05 vs. C2816 (7 nmol/kg).
