Table 2.

Terminal blood glucose, and plasma concentrations of liver enzymes, lipids and exocrine pancreatic enzymes in diet-induced obese mice following 10 days of treatment with vehicle, AC3174, AC17022, combination of AC3174 + AC170222, fusion peptide C2816, or (pGlu-Gln)-CCK-8/exendin-4. *p < 0.05 vs. vehicle, ˆp < 0.05 vs. AC3174, +p < 0.05 vs. AC170222, #p < 0.05 vs. AC3174 + AC170222; †p < 0.05 vs. (pGlu-Gln)-CCK-8/exendin-4.

	Vehicle	AC3174	AC170222	AC3174 + AC170222	C2816	(pGlu-Gln)-CCK-8/exendin-4
Glucose (mg/dL)	298 ± 15	266 ± 15	280 ± 11	260 ± 12	183 ± 9*ˆ+#†	314 ± 11#
Insulin (ng/mL)	14.3 ± 5.2	6.4 ± 0.7	11.3 ± 4.1	5.0 ± 0.5	2.1 ± 0.8	13.8 ± 4.8
ALT (U/L)	56 ± 7	57 ± 15	86 ± 32	53 ± 6	132 ± 27#	56 ± 11
AST (U/L)	79 ± 11	71 ± 11	95 ± 27	67 ± 6	204 ± 52*ˆ+#†	81 ± 10
Cholesterol (mg/dL)	213 ± 6	219 ± 13	192 ± 28	164 ± 15	73 ± 17*ˆ+#†	192 ± 19
Triglycerides (mg/dL)	112 ± 10	108 ± 7	114 ± 6	94 ± 8	73 ± 7*ˆ+†	118 ± 11
Amylase (U/L)	2667 ± 94	2795 ± 83	2759 ± 75	2516 ± 131	2275 ± 171ˆ†	2858 ± 115
Lipase (U/L)	25 ± 1	50 ± 13	77 ± 49	118 ± 77	373 ± 103*ˆ+#†	46 ± 17