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Estimated lung density decline (adjusted lung density at 15th percentile at total lung capacity) over 48 months, using data from the mixed-effects regression model applied to each trial separately (the Randomized, Placebo-Controlled Trial of Augmentation Therapy in Alpha-1 Proteinase Inhibitor Deficiency [RAPID-RCT] and RAPID Open Label Extension [RAPID-OLE] trial intention-to-treat population).
