Table 2.
Baseline Characteristics of Adults With Interstitial Disease and Acute Respiratory Failure
| Variable | IPF (n = 15) | CTD (n = 23) | Other ILD (n = 36) | Unclassifiable ILD (n = 52) |
|---|---|---|---|---|
| Baseline characteristics | ||||
| Age, median (IQR), y | 65 (59-69) | 58 (44-68) | 61 (50.5-66) | 62.5 (55.5-72.5) |
| Male, No. (%) | 12 (80) | 8 (34.8) | 20 (55.6) | 26 (50) |
| BMI, median (IQR), kg/m2 | 24.7 (22.3-28.4) | 25.1 (23-29.2) | 26.1 (22.9-29.3) | 26.9 (20.6-30.2) |
| Ever-smoker, No. (%) | 13 (86.7) | 10 (43.5) | 21 (58.3) | 23 (44.2) |
| Supplemental oxygen use, No. (%) | 13 (86.7) | 17 (73.9) | 27 (75) | 32 (61.5) |
| Supplemental oxygen flow rate, median (IQR), L/min | 5 (3-8) | 3 (0-3) | 3 (0.5-4) | 2 (0-4) |
| In-hospital characteristics | ||||
| SAPS-II, median (IQR) | 33 (27-38) | 32 (24-42) | 30.5 (24-37.5) | 31.5 (26.5-42) |
| NIPPV only, No. (%) | 2 (13.3) | 5 (21.7) | 8 (22.2) | 12 (23.1) |
| Invasive device within 24 h of admission | 12 (80) | 13 (56.5) | 22 (61.1) | 33 (63.5) |
| Ambulation within 24 h of admission, No. (%) | 4 (27) | 8 (34.8) | 9 (25) | 14 (26.9) |
| Admission laboratory values, median (IQR) | ||||
| pH | 7.44 (7.40-7.47) | 7.38 (7.30-7.42) | 7.44 (7.36-7.47) | 7.40 (7.32-7.45) |
| Partial pressure of carbon dioxide | 38 (33-59) | 45 (38-60) | 44.5 (39-53.5) | 46.5 (38.5-61.5) |
| White blood cell count | 10.4 (6.8-13.7) | 12.6 (9.8-17.2) | 12.9 (10.1-18.6) | 15.5 (12.4-17.3) |
| Platelets | 195 (164-238) | 301 (210-246) | 235.5 (161.5-317) | 217 (155-298) |
| Serum creatinine | 0.65 (0.56-1.38) | 0.93 (0.68-1.62) | 0.79 (0.56-0.94) | 0.84 (0.62-1.3) |
| Serum bicarbonate | 26 (23-34) | 24 (19-28) | 28 (24-32) | 27 (23.5-31) |
| Serum albumin | 3.1 (2.7-3.8) | 3.2 (2.8-3.6) | 3.4 (3.2-3.7) | 3.2 (2.8-3.6) |
| Serum total bilirubin | 0.7 (0.5-0.9) | 0.6 (0.4-0.9) | 0.6 (0.4-0.95) | 0.65 (0.5-0.95) |
| Do not resuscitate order on admission, No. (%) | 4 (26.7) | 3 (13) | 2 (5.6) | 10 (19.2) |
| Listed for lung transplant during ICU stay, No. (%) | 6 (40) | 2 (8.7) | 9 (25) | 4 (7.7) |
| ICU length of stay, d | 8 (4-12) | 9 (6-15) | 6 (4-9.5) | 4.5 (3-12) |
| Hospital length of stay, d | 9 (5-14) | 19 (9-32) | 13 (6.5-22.5) | 9 (13-17.5) |
Data are expressed as No. of patients (%) and median (IQR). CTD = connective tissue disease; ILD = interstitial lung disease; IPF = idiopathic pulmonary fibrosis; IQR = interquartile range; NIPPV = noninvasive positive pressure ventilation; SAPS = Simplified Acute Physiology Score.