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. 2018 May 8;13:30–44. doi: 10.1016/j.molmet.2018.05.004

Figure 6.

Figure 6

Osteoglycin modulates central NPY to alter food intake. Cumulative food intake in wildtype mice treated with either osteoglycin (OGN) or PBS control (A) prior to treatment and (B) immediately following treatment. (C) Total food intake during the first 6 h following OGN or PBS treatment. (D) Representative photomicrographs and (E) quantification showing cfos expression in the Arcuate nucleus of the hypothalamus following i.p. injections of either saline or OGN. (F) Representative photomicrographs and (G) quantification showing cfos (red), NPY (green) and cfos/NPY co-localization (yellow) expression in the Arcuate nucleus of the hypothalamus following icv injections of either saline or OGN. (H) qPCR of NPY mRNA levels in the Arcuate of WT and Ogn−/− brains. Data are means ± SEM of at least 4 per group, * = p < 0.05, ** = p < 0.01, *** = p < 0.001 as indicated. Scalebar represents 100 μm.