Table 2.

The top 10 enriched Gene Ontology terms of Differentially Expressed Genes (DEGs), sorted by P value in ascending order. On the basis of DEGs, the network analysis identified the modulated pathways are listed. All the genes are upregulated. The most commonly activated targetable genes are associated with FGF signaling pathways.

#	Maps	Total	p-value	FDR	In Data	Network Objects from Active Data
1	Protein folding and maturation_POMC processing	30	7.737E-21	3.474E-18	16	CLIP, ACTH, alpha-MSH beta-Endorphin extracellular region, proACTH, POMC, N-POMC, gamma-MSH, N-POC, beta-LPH, gamma-LPH, ACTH 1-17, DA-alphaMSH, gamma2-MSH, gamma3-MSK beta-MSH
2	Development_FGF-family signaling	52	1.569E-09	3.522E-07	11	FGF2, FGF8, FGF9, FGF3, FGF7, FGF10, FGF6, FGF 19, FGFR1, FGF1, FGF4
3	Neurophysiological process_Receptor-mediated axon growth repulsion	46	1.650E-05	1.853E-03	7	PlexinA2, Ephexin, F-Actin cytoskeleton, Fer, c-Fes, Plexin A1, Actin cytoskeletal
4	FGF signaling in pancreatic cancer	46	1.650E-05	1.853E-03	7	FGF2, FGF7, FGF5, FGF10, FGFR1, HBP17, FGF1
5	Signal transduction_mTORC1 downstream signaling	61	7.790E-04	6.996E-02	6	4E-BP2, CLIP170, 4E-BP1, LIPIN1, elF4A, elF4E
6	Development_Growth factors in regulation of oligodendrocyte precursor cell proliferation	67	1.281 E-03	9.584E-02	6	FGF2, FGF8, FGF18, FGF17, FGFR1, mTOR
7	Cytoskeleton remodeling_Reverse signaling by Ephrin-B	32	2.494E-03	1.578E-01	4	SDF-1, FAP-1, Actin cytoskeletal, F-Actin
8	Translation_Regulation of EIF4F activity	54	2.812E-03	1.578E-01	5	4E-BP1, elF4A, elF4E, mTOR, elF4G2
9	Androgen receptor activation and downstream signaling in Prostate cancer	110	3.727E-03	1.859E-01	7	FGF2, FGF8, SPRY2, ESR2, FGFR1, FEN1, FGF1
10	Development_Mu-type opioid receptor signaling	38	4.706E-03	1.951E-01	4	4E-BP2, beta-Endorphin extracellular region, 4E-BP1, mTOR