Figure 2.

Cell migration on 2D substrates. (A) The contours of the cell boundary velocity, $v_0$, are shown as functions of actin polymerization rate $J_{\text{actin}}$ and focal adhesion friction coefficient ${\eta }_{\text{st}}$. $J_{\text{actin}}/{\text{Θ}}_n$ is a measure of actin velocity at the cell boundary generated by actin polymerization. In the calculation, $J_{\text{actin}}$ varies and ${\text{Θ}}_n$ remains unchanged. (B) The cell boundary velocity $v_0$ is given as a function of $v_n^{\text{f}}$ for different coefficient of focal adhesion ${\eta }_{\text{st}}$. (C) The contours of $v_0$ as $J_{\text{actin}}$ and $J_{\text{water}}$ vary as shown. In 2D, $J_{\text{water}}$ does not influence cell boundary velocity. (D) The contours of $v_0$ as ${\xi }_m$ and $f_{\text{ext}}^{\text{f}}$ vary as shown. (E) The contours of $v_0$ as $f_{\text{ext}}^{\text{f}}$ and ${\eta }_{\text{st}}$ vary as shown. (F) The stall force per unit area for different ${\eta }_{\text{st}}$ is given. As expected, the magnitude of the stall force increases with increasing coefficients of focal adhesion friction or the rate of actin polymerization. To see this figure in color, go online.