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. 2018 Jun 19;114(12):2974–2985. doi: 10.1016/j.bpj.2018.05.005

Figure 11.

Figure 11

The likelihood function L(Ltdata|μ) using Eq. 27 and simulated data. We set μ = 1.5 and assign other parameters with M = 1 × 105, fmax = 2, h = 1, K = 1, and L0 = 1. The estimate derived from solving Eq. 28 is μˆ=1.502, whereas the standard method based on the sample mean yields μˆ=0.97, far lower than what is displayed in the plot.