Table 1.

Effect of trimethoxy flavones (TMF) on paclitaxel – induced tactile allodynia in mice^@

Dose of test compounds mg/kg, s.c.	Paw withdrawal response score
	7, 2′,3′ – TMF		7, 2′,4′ – TMF		7, 3′,4′ – TMF		7, 5, 4′ – TMF
	Before treatment	After treatment	Before treatment	After treatment	Before treatment	After treatment	Before treatment	After treatment
25	18.33 ± 0.42	18.66 ± 0.61	19.00 ± 0.36	18.66 ± 0.42	19.16 ± 0.44	19.00 ± 0.30	20.00 ± 0.00	19.33 ± 0.42
50	19.33 ± 0.42	17.33 ± 0.86	19.33 ± 0.42	17.33 ± 0.66	19.33 ± 0.42	17.00 ± 0.68	19.16 ± 0.40	18.00 ± 0.73
100	19.00 ± 0.68	12.66 ± 1.33*	19.66 ± 0.33	12.50 ± 0.71*	19.00 ± 0.68	13.00 ± 0.73*	19.33 ± 0.42	14.66 ± 0.42*
200	19.00 ± 0.68	4.33 ± 1.28*	19.33 ± 0.42	10.00 ± 0.57*	18.33 ± 0.61	4.00 ± 0.51*	19.53 ± 0.42	12.33 ± 0.95*

Each value represents the mean ± SEM of six observations.

The paw withdrawal response score was 19.66 ± 0.33 and 19.50 ± 0.34 before and after treatment with vehicle

The paw withdrawal response scores in morphine (10 mg/kg) treated mice were, 20.00 ± 0.00 before treatment and 3.16 ± 1.24^* after treatment.

^*P < 0.05 compared to respective value before treatment

^@All treatment groups received paclitaxel (10 mg/kg, i.p.) 24 h prior to the test. Tactile allodynia was determined before and 30 min after vehicle/morphine/trimethoxy flavones treatment on the next day.