Table 2.

Effect of trimethoxy flavones (TMF) on paclitaxel – induced cold allodynia in mice^@

Dose of test compounds mg/kg, s.c.	Paw withdrawal response score
	7, 2′,3′ – TMF		7, 2′,4′ – TMF		7, 3′,4′ – TMF		7, 5,4′ – TMF
	Before treatment	After treatment	Before treatment	After treatment	Before treatment	After treatment	Before treatment	After treatment
25	17.16 ± 0.30	17.00 ± 0.51	17.16 ± 0.30	16.50 ± 0.42	17.66 ± 0.21	17.00 ± 0.44	16.83 ± 0.49	16.66 ± 0.47
50	17.50 ± 0.84	16.33 ± 0.33	17.50 ± 0.22	14.66 ± 0.42*	17.16 ± 0.16	10.00 ± 1.25*	17.33 ± 0.33	15.83 ± 0.65*
100	17.16 ± 0.54	9.16 ± 0.87*	16.66 ± 0.61	10.50 ± 0.56*	17.00 ± 0.68	6.16 ± 1.07*	17.83 ± 0.47	12.66 ± 0.61*
200	17.66 ± 0.98	2.50 ± 0.42*	17.83 ± 0.16	7.83 ± 0.98*	16.83 ± 0.40	3.50 ± 1.05*	16.83 ± 0.47	8.50 ± 0.56*

Each value represents the mean ± SEM of six observations.

The paw withdrawal response scores were 17.66 ± 0.33 and 17.50 ± 0.34 before and after vehicle treatment.

The paw withdrawal response scores in morphine (10 mg/kg) treated mice were 18.00 ± 0.00 before treatment and 1.83 ± 0.87^* after treatment.

^*P < 0.05 compared to respective score before treatment.

^@All treatment groups received paclitaxel (10 mg/kg, i.p.) 24 h prior to the test. Cold allodynia was determined before and 30 min after vehicle/morphine/trimethoxy flavones treatment on the next day.