Table 3.

Effect of trimethoxy flavones (TMF) on paclitaxel – induced thermal hyperalgesia in mice^@

Dose of test compounds (mg/kg, s.c)	Mean increase in reaction time (seconds)
	7, 2′,3′ – TMF	7, 2′,4′ – TMF	7, 3′,4′ – TMF	7, 5, 4′ – TMF
25	1.83 ± 0.55 (8.87)	1.12 ± 0.31(5.31)	2.27 ± 0.41*(11.08)	1.04 ± 0.23(4.91)
50	5.62 ± 0.57* (27.88)	2.98 ± 0.37* (14.64)	3.64 ± 0.49* (17.95)	1.47 ± 0.37(7.07)
100	8.52 ± 0.56* (42.42)	5.69 ± 0.74* (28.23)	5.42 ± 0.91* (26.88)	3.97 ± 0.44*(19.60)
200	10.17 ± 1.09* (50.70)	7.80 ± 0.50* (38.81)	8.23 ± 0.84* (40.97)	5.86 ± 0.84*(29.08)

Each value represents the mean ± S.E.M of six observations.

The values in parenthesis indicate the percentage of maximal protective effect.

The mean increase in reaction time in vehicle treated animals was 0.06 ± 0.04 sec.

The mean increase in reaction time after morphine (10 mg/kg) treatment was 15.09 ± 0.88 sec^* (75.37%).

^*P < 0.05 compared with vehicle treatment.

^@All treatment groups received paclitaxel (10 mg/kg, i.p.) 24 h prior to the test. Thermal hyperalgesia was determined before and 30 min after vehicle/morphine/TMF treatment on the next day. The mean increase in reaction time represents the difference in time latency recorded before and after treatment with the vehicle / test compounds.