Figure 5.

Virus Spread in the Tumor following Intratumor or Intravenous Injection and Examination of Vital Organs in Infected and Non-infected Mice

(A) Whereas the IV group had a more infiltrative pattern of infection, the IT group had a more uniform leading edge of viral infectivity, likely indicating that efficacy was a direct function of oncolytic ability and effective viral delivery. (B) Representative slides of brain, kidney, liver, and spleen are shown demonstrating no differences in histopathological organ appearance based upon viral infection.