Skip to main content
. 2018 Apr 12;9:30–40. doi: 10.1016/j.omto.2018.04.002

Figure 1.

Figure 1

Genome Structure of Recombinant Measles Viruses

(A) Genome structure of engineered viruses encoding EGFP (enhanced GFP) in an additional transcription unit (ATU) upstream of the N gene as well as a synthetic microRNA target site (miRTS) box in the 3′ UTR of the N, F, H, or L gene. (B) Genome structure of engineered viruses encoding EGFP (enhanced GFP) in an additional transcription unit (ATU) upstream of the N gene as well as synthetic miRTS boxes in the 3′ UTRs of the N and F or N and L genes. (C) Sequences of four different miRTS boxes complementary to miR-7-5p, miR-122-5p, miR-124-3p, and miR-125b-5p, respectively. miRTS are underlined and separated by nonunderlined spacer nucleotides. The miRTS portions that are complementary to the microRNA seed sequences are indicated in bold print.