Figure 4.

Shear design. (A) The average cooperative response $\delta {\mathbf{R}}_r^{\mathcal{A}l}$ induced by binding at the allosteric site is shown in black arrows. (B) The average shear intensity map $E_{\text{shear}}$ reveals strain localization along a path. (C) A mint box that opens by sliding illustrates the shear mechanism. (D) A map of the average coordination number z is shown. (E) A map of the average strain B-factor SB is shown. (F) A map of the fitness cost of single-site mutation normalized by its absolute value $\mathit{\Delta }\mathcal{F}/\mathcal{F}$ is shown. (G) A map of the conservation $\text{Σ}$ in the evolution simulation is shown. (H) The overlap q_ω between the response and the vibrational modes, colored as a function of the participation ratio P_ω, shows that a single extended mode dominates the response to binding. To see this figure in color, go online.