Figure 5.

Hinge design. (A) The averaged cooperative response $\delta {\mathbf{R}}_r^{\mathcal{A}l}$ induced by binding at the allosteric site is shown in black arrows. (B) The shear intensity $E_{\text{shear}}$ of the response is given. (C) A clothespin illustrates the hinge mechanism. (D) A map of the average coordination number z is shown. (E) A map of the average strain B-factor SB is shown. (F) A map of the fitness cost of single-site mutation normalized by its absolute value $\mathit{\Delta }\mathcal{F}/\mathcal{F}$ is shown. (G) A map of the conservation $\text{Σ}$ is shown. (H) The decomposition q_ω of the response on the vibrational modes ω, colored as a function of the participation ratio P_ω, is shown. To see this figure in color, go online.