Figure 4.
Simulation results. (a) Parameter sampling results for the six selected networks show am average increase of protrusion number under the ReceptorDN condition compared to the wild-type cluster in the x axes and the wild-type cluster’s directionality in the y axes. The square box shows the region that is qualitatively consistent with the experimental results, and the number represents the number of parameter sets (out of 500,000) that produce results that are consistent with the experiments. (b) A comparison of the experimental data reported in Table 1 and simulation results for the six selected networks with fitted parameters are shown. A–F correspond to networks A through F in Fig. 2c. Error bars show the SDs. (c) Trends of the cluster’s directionality are shown for the six selected networks with fitted parameters when the mean signal is changed. (d) Trends of the cluster’s velocity are shown for the six selected networks with fitted parameters along the migration path. To see this figure in color, go online.