Table 2. List of few marine microbial species reported to produce bioactive metabolites with antibiofilm and antifouling activities (Abu Sayem et al., 2011; Arai, Niikawa & Kobayashi, 2013; Busetti et al., 2015; Dos Santos et al., 2010; Estrela & Abraham, 2016; Fusetani, 2011; Hong & Cho, 2013; Jiang et al., 2011; Salta et al., 2013; Satheesh, Ba-Akdah & Al-Sofyani, 2016; Scopel et al., 2014; Shao et al., 2015; Shao et al., 2011; Yang et al., 2007).

Microorganism	Bioactive compound	Biological activity	Effects against	Relevance
Bioactive compounds isolated from marine bacteria
Bacillus licheniformis	α-D-galactopyranosyl-(1→2)-glycerol-phosphate	Antibiofilm	Escherichia coli and Pseudomonas fluorescens	Clinical
Alteromonas sp.	Ubiquinone-8	Antifouling	Larval settlement of barnacle Balanus amphitrite	Environmental
Acinetobacter sp.	6-bromoindole-3-carboxaldehyde	Antifouling	Larval settlement of barnacle Balanus amphitrite	Environmental
Pseudomonas sp.	Pyolipic acid	Antifouling	Larval settlement under laboratory and field experiment assays	Environmental
Pseudomonas sp.	Phenazine-1-carboxylic acid	Antifouling	Larval settlement under laboratory and field experiment assays	Environmental
Pseudomonas sp.	2-alkylquinol-4-ones	Antifouling	Larval settlement under laboratory and field experiment assays	Environmental
Streptomyces praecox	Diketopiperazines	Antifouling	Larval settlement under laboratory and field experiment assays	Environmental
Streptomyces violaceoruber	3-octa-1′,3′-dienyl-4-methylfuran-2(5H)-one	Antifouling	Zoospores of Ulva pertusa, the diatom Navicula annexa, and the mussel Mytilus edulis	Environmental
Streptomyces violaceoruber	3-octa-1′-enyl-4-methylfuran-2(5H)-one	Antifouling	Zoospores of Ulva pertusa, the diatom Navicula annexa, and the mussel Mytilus edulis	Environmental
Vibrio sp. QY101	Exopolysaccharide A101	Antibiofilm	Pseudomonas aeruginosa FRD1	Clinical
Bioactive compounds isolated from marine fungi
Letendraea helminthicola	3-methyl-N-(2-phenylethyl) butanamide	Antifouling	Larval settlement of barnacle Balanus amphitrite	Industrial/Environmental
Scopulariopsis sp.	Dihydroquinolin-2(1H)-one	Antifouling	Larval settlement of barnacle Balanus amphitrite	Industrial/Environmental
Letendraea helminthicola	Cyclo (D-Pro-D-Phe)	Antifouling	Larval settlement of barnacle Balanus amphitrite
Cochliobolus lunatus	Resorcyclic acid lactones	Antifouling	Larval settlement of barnacle Balanus amphitrite	Industrial/Environmental
Emericella variecolor	Ophiobolin K	Antibiofilm	Mycobacterium bovis	Clinical
Emericella variecolor	6-epi-ophiobolin K	Antibiofilm	Mycobacterium smegmatis	Clinical
Emericella variecolor	6-epi-ophiobolin	Antibiofilm	Mycobacterium smegmatis	Clinical
Unidentified marine fungus	Mevalonolactone	Antibiofilm	Staphylococcus epidermidis	Clinical
Marine Penicillium sp.	Cyclo(L-Tyr-L-Leu)	Antibiofilm	Staphylococcus epidermidis	Clinical/Environmental
Penicillium commune	Cyclo(L-Leu-L-Pro)	Antibiofilm	Staphylococcus aureus	Clinical/Environmental
Cladosporium sp.	F14 cyclo-(Phe-Pro)	Antibiofilm	Loktanella hongkongenis, Micrococcus luteus and Ruegeria sp.	Clinical/Environmental
Cladosporium sp.	cyclo-(Val-Pro) 4	Antibiofilm	Loktanella hongkongenis	Clinical/Environmental
Aspergillus flavipes	Flavipesin A 49	Antibiofilm	Staphylococcus aureus and Bacillus subtilis	Clinical
Bioactive compounds isolated from marine algae
Chondrus crispus	(+)—Usnic acid	Antibiofilm	Cobetia marina and Marinobacter hydrocarbonoclasticus	Environmental
Chondrus crispus	Juglone	Antibiofilm	Cobetia marina and Marinobacter hydrocarbonoclasticus	Environmental
Laurencia elata	Elatol	Antifouling	Leishmania amazonensis	Clinical
Halidrys siliquosa	Organic extract	Antibiofilm	Staphylococcus; Streptococcus; Enterococcus; Pseudomonas; Stenotrophomonas; and Chromobacterium	Clinical