Table 1.
Baseline characteristics of the study population
| Variables | Subsample of Rotterdam Study (n = 458) |
|---|---|
| Demographic and vascular risk factors | |
| Age, yr, mean (SD) | 67.8 (7.7) |
| Women, n (%) | 232 (50.7) |
| Education, yr, mean (SD) | 10.7 (3.4) |
| Mean arterial blood pressure, mmHg, mean (SD) | 96.5 (12.7) |
| Total cholesterol, mmol/L, mean (SD) | 5.7 (0.93) |
| Diabetes mellitus, n (%) | 55 (12.1) |
| Smoker, ever, n (%) | 317 (69.7) |
| APOE-ε4 carriers, n (%) | 137 (30) |
| Plasma levels of Aβ isoforms, pg/ml, mean (SD) | |
| Aβ1–38 | 19.4 (4.3) |
| Aβ1–40 | 186.1 (35.9) |
| Aβ1–42 | 56.3 (6.2) |
| MRI markers, ml, mean (SD) | |
| White matter volume | 354.1 (85.4) |
| Gray matter volume | 522.7 (55.8) |
| Intracranial volume | 1126.2 (113.9) |
| Hippocampus volume | 6.4 (0.9) |
Abbreviations: , APOE Apolipoprotein, Aβ Amyloid-β, MRI Magnetic resonance imaging