Table 3.
Intervention effect on incident all-cause dementia across the models, by LIBRA group
| LIBRA group | Intervention, n/N (%) | Control, n/N (%) | Hazard ratio (95% CI) | p value for interaction | |
|---|---|---|---|---|---|
| Model 1: LIBRA index | Low | 33/567 (5.8%) | 43/524 (8.2%) | 0.71 (0.45–1.12) | Ref. |
| Intermediate | 39/576 (6.8%) | 32/505 (6.3%) | 1.06 (0.66–1.69) | 0.23 | |
| High | 41/606 (6.8%) | 32/496 (6.5%) | 1.02 (0.64–1.62) | 0.27 | |
| Model 2: LIBRA index including education | Low | 28/555 (5.0%) | 39/498 (7.8%) | 0.64 (0.40–1.05) | Ref. |
| Intermediate | 38/525 (7.2%) | 31/482 (6.4%) | 1.11 (0.69–1.79) | 0.12 | |
| High | 46/660 (7.0%) | 35/525 (6.7%) | 1.03 (0.66–1.59) | 0.17 | |
| Model 3: LIBRA index including age, sex and education | Low | 32/564 (5.7%) | 33/515 (6.4%) | 0.88 (0.54–1.43) | Ref. |
| Intermediate | 35/568 (6.2%) | 34/510 (6.7%) | 0.91 (0.57–1.47) | 0.94 | |
| High | 45/608 (7.4%) | 38/480 (7.9%) | 0.92 (0.59–1.41) | 0.92 | |
| Model 4: LIBRA index excluding coronary heart disease | Low | 36/559 (6.0%) | 45/559 (8.1%) | 0.75 (0.48–1.16) | Ref. |
| Intermediate | 35/570 (6.1%) | 28/477 (5.9%) | 1.05 (0.64–1.72) | 0.32 | |
| High | 42/580 (7.2%) | 34/489 (7.0%) | 1.01 (0.64–1.59) | 0.34 |
LIBRA LIfestyle for BRAin Health, CI confidence interval, Ref. reference category