Table 4.
Interaction between ALDH2 rs671 polymorphism and fried food intake on CAD risk
| ALDH2 rs671 polymorphism genotype | |||||
|---|---|---|---|---|---|
| Non-risk allele carriers (G/G) | Risk allele carriers (A/A + A/G) | ||||
| N cases/controls | OR† (95% CI) | N cases/controls | OR† (95% CI) | OR† (95% CI) for A/A + G/G within strata of fried food intake | |
| No fried food intake | 28/116 | 24/97 | |||
| 1.0 | 0.954 (0.509–1.786) P = 0.882 |
0.954 (0.509–1.786) P = 0.882 |
|||
| Regular fried food intake | 44/158 | 65/124 | |||
| 1.084 (0.626–1.878) P = 0.773 |
1.859 (1.074–3.217)
P = 0.027 |
1.715 (1.057–2.780)
P = 0.029 |
|||
| OR† (95% CI) for regular fried food intake within strata of genotype | 1.084 (0.626–1.878) P = 0.773 |
1.949 (1.117–3.400)
P = 0.019 |
|||
Measure of interaction on additive scale: RERI (95% CI) = 0.821 (−0.007 to 1.649); P value = 0.052
†Adjusted for age, sex, BMI, SBP, TC level, TG level, HDL-C level, current smoking, current alcohol intake, and history of diabetes mellitus
Italic values are statistically significant with P value < 0.05 and maintains significance using the Benjamini–Hochberg procedure with the false discovery rate at 0.12