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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: J Pathol. 2018 Apr 14;245(2):132–137. doi: 10.1002/path.5066

Figure 1.

Figure 1

A generalized pattern for the induction of pyloric phenotype reparative metaplasias. Injury to the lining of gastrointestinal mucosae by various acute or chronic maladies leads to the evolution of metaplastic glands which recapitulate the structure of mucous-secreting glands of the distal stomach with TFF2/Muc6-expressing mucous cells at the bases and TFF1/Muc5AC-expressing cells towards the lumen. These reparative glands can be identified histologically and immunohistologically by various names, but all share a common pyloric gland phenotype.