Table 4.

Summary of Klimisch scores for data reliability (adapted from Klimisch et al., 1997) (Note “restriction”, as part of scores 1 and 2, implies restricted quality)

Score	Description	Summary
1	Reliable without restriction	Well documented and accepted study or data from the literature Performed according to valid and/or accepted test guidelines (e.g., OECD) Preferably performed according to good laboratory practices (GLP)
2	Reliable with restriction	Well documented and sufficient Primarily not performed according to GLP Partially complies with test guideline
3	Not reliable	Inferences between the measuring system and test substance Test system not relevant to exposure Method not acceptable for the endpoint Not sufficiently documented for an expert review
4	Not assignable	Lack of experimental details Referenced from short abstract or secondary literature