Table 5.
Mediating effects1 of indicators of frailty on the association between cancer and sepsis. Among 16,632 White participants with 873 first sepsis events.
| Natural Indirect Effect2 (Mediation Effect) | Natural Direct Effect3 | Percent Mediated4 (%) (Log Hazard Scale) | |||
|
| |||||
| Mediators | HR | 95% CI5 | HR | 95% CI5 | |
|
| |||||
| Weakness | 1.007 | 1.002 – 1.015 | 2.552 | 2.395 – 2.764 | 0.79% |
| Exhaustion | 1.003 | 1.000 – 1.007 | 2.563 | 2.401 – 2.767 | 0.28% |
| Low Physical Activity | 1.004 | 1.000 – 1.008 | 2.555 | 2.401 – 2.758 | 0.47% |
| Frailty | 1.004 | 1.001 – 1.008 | 2.555 | 2.401 – 2.756 | 0.47% |
| # Frailty Indicators | 1.004 | 1.001 – 1.008 | 2.555 | 2.401 – 2.758 | 0.45% |
|
| |||||
| Total Effect (Risk of Sepsis) | |||||
|
| |||||
| No. Sepsis Events (%) | Mean Survival Time (95% CI)7 | Hazard Ratio (95% CI)8 | |||
|
| |||||
| Cancer Survivors | 258 (13.33) | 8.52 (8.42 – 8.62) | 2.52 (2.17 – 2.93) | ||
| No Cancer History | 615 (4.18) | 8.82 (8.80 – 8.84) | Ref | ||
1
Models adjusted for age, sex, and comorbidity score.
2
Natural Indirect Effect (i.e., the effect of the cancer on sepsis incidence through the mediator)
3
Natural Direct Effect (i.e., the effect of the cancer on sepsis incidence NOT through mediator)
4
Percent Mediated = Percent of the total association between the cancer and sepsis incidence that was mediated on the log hazard scale.
5
95% Confidence intervals (CIs) estimated using 500 bootstrapped resamples.
6
% represents the proportion within cancer group with sepsis event.
7
Mean survival time in years.
8
Estimated from Cox proportional hazards model.