Table 4.
Baseline characteristic differences by CART terminal nodes
| CV RMSE = 1.16 | |||||
|---|---|---|---|---|---|
|
| |||||
| Characteristic | Node 1 (n=11) | Node 2 (n=23) | Node 3 (n=25) | Node 4 (n=54) | Node 5 (n=7) |
| Continuous variables, Mean (SD) | |||||
| Peanut SPT | 4.27 (1.31) | 5.78 (2.81) | 4.88 (1.84) | 5.08 (2.12) | 5.50 (1.89) |
| FEV1 at DBPCFC | 92.18 (9.53) | 99.4 (13.87) | 91.24 (8.85) | 96.5 (11.59) | 94.57 (14.30) |
| FEV1/FVC ratio at DBPCFC | 0.75 (0.05) | 0.88 (0.05) | 0.81 (0.07) | 0.85 (0.06) | 0.80 (0.10) |
| Number of food allergies | 3.00 (3.22) | 4.00 (2.59) | 4.36 (2.66) | 3.65 (2.43) | 2.57 (2.15) |
| BMI | 18.63 (3.91) | 20.12 (6.79) | 19.44 (4.48) | 18.32 (3.89) | 21.09 (6.24) |
| CD63 ratio | 0.20 (0.16) | 0.20 (0.17) | 1.73 (1.45) | 2.01 (1.12) | 10.72 (4.41) |
| Continuous Variables, Median (1st quartile, 3rd quartile) | |||||
| Age at enrollment | 11 (9, 16) | 9 (8, 14.5) | 12 (9, 16) | 10.5 (8, 14) | 13 (10.5, 2.5) |
| Peanut diagnosis age | 2 (1, 3) | 2 (1, 3) | 1 (0.8, 2) | 1.5 (1, 2) | 1.5 (1, 3.5) |
| Peanut allergy duration | 9.2 (6.8, 13.3) | 8 (6, 13) | 9.3 (7.5, 13.3) | 8.7 (7, 12) | 11.5 (9.8, 29.5) |
| Ara h 1 (ng/L) | 1.2 (0, 3.6) | 0.6 (0, 26.0) | 52.5 (3.0, 135) | 82.6 (10.2, 224) | 134.7 (60.0, 232) |
| Ara h 2 (ng/L) | 6.3 (1.8, 14.0) | 8.9 (1.4, 64.8) | 75.6 (25.1, 169) | 152.9 (52.6, 409) | 193.5 (104.1, 439) |
| Ara h 3 (ng/L) | 0 (0, 1.3) | 0.4 (0, 3.0) | 4.1 (0.5, 40.3) | 18.2 (3.0, 46.4) | 25.9 (14.0, 43.4) |
| Ara h 8 (ng/L) | 0 (0, 1.3) | 0.3 (0, 12.2) | 0 (0, 0.7) | 0 (0, 1.5) | 0.4 (0.1, 2.2) |
| Ara h 9 (ng/L) | 0 (0, 12.1) | 0 (0, 0.2) | 0 (0, 0) | 0 (0, 0) | 0.5 (0, 2.6) |
| Peanut IgG4 (μg/L) | 480 (255, 715) | 360 (210, 1520) | 940 (350, 1600) | 910 (402, 2388) | 2460 (1055, 4535) |
| Peanut IgE (ng/L) | 14.4 (2.9, 65.8) | 47.3 (8.5, 219) | 192.8 (36.1, 312) | 316.0 (147, 767) | 446.5 (218, 1252) |
| Total IgE (ng/L) | 1342.0 (708, 3370) | 1193.2 (603, 2302) | 1281 (683, 2403) | 1339.6 (699, 3226) | 3991.8 (473, 8808) |
| Categorical Variables, Percent | |||||
| Male | 81.8 | 82.6 | 68 | 61.1 | 42.9 |
| Caucasian | 90.9 | 73.9 | 64 | 68.5 | 71.4 |
| Asian | 18.2 | 43.5 | 32 | 37 | 28.6 |
| Black | 0 | 4.3 | 4 | 1.9 | 0 |
| Non-Hispanic | 100 | 95.7 | 100 | 96.3 | 100 |
| Peanut Dx only | 54.5 | 17.4 | 24 | 29.6 | 57.1 |
| Tree nut Dx | 36 | 70 | 68 | 59 | 43 |
| History of Asthma | 63.6 | 52.2 | 100 | 53.7 | 100 |
| History of AR | 72.7 | 87 | 84 | 66.7 | 71.4 |
| History of AD | 63.6 | 73.9 | 84 | 72.2 | 42.9 |
AD, Allergic dermatitis; AR, allergic rhinitis; BMI, body mass indicator; CART, classification and regression trees; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; DBPCFC, double blind placebo controlled food challenge; SPT, skin prick test.