Table 1.
Demographic, disease and hormonal characteristics of study participants.
| Women | Men | p-value | |
|---|---|---|---|
|
| |||
| N | 91 | 72 | |
|
| |||
| Demographic characteristics | |||
|
| |||
| Age (years, mean (SD)) | 38.7 (8.5) | 39.9 (9.0) | 0.40 |
|
| |||
| % White^ | 97.8 | 94.4 | 0.41 |
|
| |||
| Disease characteristics | |||
|
| |||
| Disease duration (years, mean (SD)) | 3.0 (1.4) | 4.4 (2.5) | <0.001 |
|
| |||
| % Relapsing-remitting | 83.5 | 93.1 | 0.11 |
|
| |||
| EDSS (median (range)) | 1 (0, 3.5) | 1 (0, 3.5) | 0.097 |
|
| |||
| SDMT (mean (SD))& | 56.9 (10.4) | 55.3 (11.9) | 0.55 |
|
| |||
| CES-D (mean (SD))# | 10.8 (9.0) | 7.7 (6.8) | 0.043 |
|
| |||
| Disease modifying therapy at blood draw (N) | 0.24 | ||
| None | 57 | 34 | |
| Interferon | 18 | 22 | |
| Glatiramer acetate | 13 | 12 | |
| Other | 3 | 4 | |
|
| |||
| Endocrine Variables | |||
|
| |||
| Leptin (ng/mL) | 22.6 (16.9) | 8.8 (5.9) | <0.001 |
|
| |||
| a-FABP (ng/mL) | 27.7 (20.7) | 20.7 (11.0) | 0.007 |
|
| |||
| BMI, kg/m2 (mean (SD))* | 26.6 (6.5) | 28.0 (4.3) | 0.16 |
|
| |||
| 25(OH)VitD(ng/mL) | 30.2 (12.2) | 26.5 (9.6) | 0.033 |
|
| |||
| Testosterone (ng/dL) | 17.8 (17.2) | 335.7 (124.7) | <0.001 |
BMI: body mass index. CES-D: for Epidemiologic Studies Depression scale. EDSS: Expanded Disability Status Scale. 25(OH)VitD: 25-hydroxy-vitamin D; a-FABP: adipocyte-fatty acid binding protein. SD: standard deviation. SDMT: Symbol Digit Modalities Test.
^
Two women’s race was listed as unknown or not reported.
&
35 women and 30 men had SDMT scores to contribute to this analysis
#
62 women and 48 men had CES-D scores to contribute to this analysis
*
73 women and 62 men contributed a BMI measurement.