. Author manuscript; available in PMC: 2020 Mar 1.

Published in final edited form as: Mult Scler. 2018 Jan 11;25(3):344–351. doi: 10.1177/1352458517750768

Table 3.

Associations between adiposity markers and secondary outcome: time to next relapse

	UNIVARIATE ASSOCIATIONS			MULTIVARIATE ASSOCIATIONS
	All subjects	Women	Men	All subjects	Women	Men
Time to next relapse (N=163) – a positive value indicates worsening function
Adiposity Markers
Leptin	0.97 (0.66)	0.99 (0.88)	0.93 (0.82)
a-FABP	0.95 (0.47)	0.93 (0.42)	1.10 (0.54)	0.96 (0.51)	0.93 (0.42)	1.12 (0.47)
Additional markers
25(OH)VitD	1.12 (0.26)	1.15 (0.24)	0.96 (0.86)	1.11 (0.29)	1.13 (0.32)	0.96 (0.86)
Testosterone	1.00 (0.98)	1.10 (0.28)	1.01 (0.69)	1.00 (0.96)	1.10 (0.32)	1.01 (0.54)

25(OH)VitD: 25-hydroxy-vitamin D; a-FABP: adipocyte-fatty acid binding protein

Time to next relapse: cox proportional hazards ratio increase in time to next relapse for one unit increase in each of the hormone measures (p-value). Adjusted for age, disease duration and type.